What is Barrett’s Esophagus? (Definition)
Barrett’s esophagus sometimes referred to as Barrett syndrome or columnar epithelium lined lower oesophagus (CELLO) is identified by an abnormal change (metaplasia) in the cells of the lower portion of the esophagus. The condition is characterized by the replacement of the normal stratified squamous epithelium lining of the esophagus by simple columnar epithelium with goblet cells (which are usually found lower in the gastrointestinal tract). The medical significance of Barrett’s esophagus is its strong association (about 0.5% per patient-year) with esophageal adenocarcinoma, a form of cancer.
Barrett’s Esophagus Symptoms and Signs
Tissue changes which identify characterize Barrett’s esophagus cause no symptoms. Symptoms associated with GERD include:
- Frequent heartburn
- Difficulty swallowing food
- Less commonly, chest pain
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