Cancer News

Screening with frequent personalized CA125 testing may improve detection of ovarian cancer in high-risk women

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(SOURCE: MASSACHUSETTS GENERAL HOSPITAL) – The combined results of two ovarian cancer screening trials suggest that a personalized strategy involving frequent screening of high-risk women could improve the chance that tumors are detected at early stages when they are easier to treat. As reported in a paper published in Clinical Cancer Research, these trials imply that a […]

Cancer News

Molecular “on switch” could point to treatments for pediatric brain tumor

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(SOURCE: MASSACHUSETTS GENERAL HOSPITAL) – Massachusetts General Hospital (MGH) researchers have identified a mechanism that controls the expression of genes regulating the growth of the most aggressive form of medulloblastoma, the most common pediatric brain tumor. In their report published online in Cancer Discovery, the team also identifies potential targets for future treatments. “We set out […]

Breast Cancer News

‘Sweet Spot’ for Additional Breast Imaging Found

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(SOURCE: RUSH UNIVERSITY MEDICAL CENTER) – Breast cancer detection increases significantly when radiologists recall mammogram patients for additional imaging more often than recommended by the current guidelines, according to a study by a radiologist at Rush. The study determined that the “sweet spot” for finding breast cancer is in the recall range of 12 to 14 percent, compared […]

Cancer News

Adding antiandrogen therapy to radiation therapy improves survival in recurrent prostate cancer

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(SOURCE: MASSACHUSETTS GENERAL HOSPITAL) – A nearly two-decades-long clinical trial has demonstrated that adding antiandrogen therapy to radiation therapy can improve the survival of prostate cancer patients who have evidence of disease recurrence after radical prostatectomy.  The study conducted by the NRG Oncology Radiation Therapy Oncology Group appears in the February 2  New England Journal of […]

Breast Cancer News

Big data brings breast cancer research forwards by ‘decades’

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(SOURCE: CANCER RESEARCH UK) – Scientists have created a ‘map’ linking the shape of breast cancer cells to genes turned on and off, and matched it to real disease outcomes, which could one day help doctors select treatments, according to a study published in Genome Research today (Wednesday).* In a revolutionary new approach, Cancer Research UK-funded scientists […]

Cancer News

Hormone may offer new contraceptive that protects ovaries from chemotherapy

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(SOURCE: MASSACHUSETTS GENERAL HOSPITAL) – A naturally occurring hormone that plays an important role in fetal development may be the basis for a new type of reversible contraceptive that can protect ovaries from the damage caused by chemotherapy drugs. In their report receiving online publication in PNAS, a team from the Pediatric Surgical Research Laboratories in the […]

Cancer News

Ovarian Cancer Treatment News: Murine study finds potential boost for ovarian cancer drug Olaparib

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(SOURCE: ROCKEFELLER UNIVERSITY PRESS) – Researchers from the Chinese Academy of Sciences have discovered that the metabolic enzyme phosphoglycerate mutase 1 (PGAM1) helps cancer cells repair their DNA and found that inhibiting PGAM1 sensitizes tumors to the cancer drug Olaparib (Lynparza). Their findings in the study “Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair […]

Cancer News

Leukemia Diagnosis Research News: Advances prompt release of new recommendations for diagnosis, management of adult AML

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(SOURCE: OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER) – An international panel of experts has released updated evidence-based and expert-opinion-based recommendations for the diagnosis and treatment of acute myeloid leukemia (AML) in adults. The recommendations were issued by the European LeukemiaNet (ELN) and published in the journal Blood. The paper’s senior author was Clara D. Bloomfield, MD, Distinguished […]

Cancer News

Cancer Research News: TINY EXPORTS SIGNAL BIG SHIFTS IN CANCER TISSUE, RESEARCHERS FIND

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(SOURCE: UNIVERSITY OF ILLINOIS) – Microscopic shifts in metabolism and increases in tiny transport vesicles out of tumor cells preface larger changes to the tumor environment and could prepare the way for cancerous cells to spread and metastasize, University of Illinois researchers report. They saw cancer-causing biological events at both the molecular and tissue scales as […]

Breast Cancer News

Breast Cancer Treatment News: Natural compound could improve treatment of triple-negative breast cancer

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(SOURCE: UNIVERSITY OF MISSOURI-COLUMBIA) – More than 100 women die from breast cancer every day in the United States. Triple-negative breast cancers, which comprise 15 to 20 percent of all breast tumors, are a particularly deadly type of breast disease that often metastasize to distant sites. Now, University of Missouri researchers have found that luteolin, a natural […]

Cancer News

Cancer Treatment News: Study unveils new way to starve tumors to death

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(SOURCE: WASHINGTON UNIVERSITY SCHOOL OF MEDICINE) – For decades, scientists have tried to halt cancer by blocking nutrients from reaching tumor cells, in essence starving tumor cells of the fuel needed to grow and proliferate. Such attempts often have disappointed because cancer cells are nimble, relying on numerous backup routes to continue growing. Now, scientists at Washington […]

Breast Cancer News

Timing of chemo affects inflammation, mice study suggests

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(SOURCE: THE OHIO STATE UNIVERSITY) – Finding ‘sweet spot’ for drug administration could help patients. The time of day that breast cancer chemotherapy drugs are given affects the amount of damaging inflammation in the body, a new study in mice suggests. That’s important because inflammation, particularly in the brain, is believed to contribute to many of […]

Cancer News

Leukemia Treatment Research News: Research leads to new treatment recommendations for a high-risk pediatric leukemia

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(SOURCE: ST. JUDE CHILDREN’S RESEARCH HOSPITAL) – International researchers led by St. Jude Children’s Research Hospital have identified genetic alterations that can be used to guide treatment of pediatric acute megakaryoblastic leukemia, which has a dismal prognosis. Research led by St. Jude Children’s Research Hospital has identified three genetic alterations to help identify high-risk pediatric patients with […]

Cancer News

Cervical Cancer Research News: TCGA study identifies genomic features of cervical cancer

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(SOURCE:  NIH/NATIONAL CANCER INSTITUTE) – Investigators with The Cancer Genome Atlas (TCGA) Research Network have identified novel genomic and molecular characteristics of cervical cancer that will aid in the subclassification of the disease and may help target therapies that are most appropriate for each patient. The new study, a comprehensive analysis of the genomes of 178 […]

Cancer News

Cancer Research News: On target: UNC researcher arms platelets to deliver cancer immunotherapy

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(SOURCE: UNIVERSITY OF NORTH CAROLINA HEALTH CARE) – UNC, NCSU biomedical engineering research team’s findings show that engineered platelets can deliver antibodies to kill cancer cells before they can grow or spread elsewhere in the body. After surgery to remove a cancerous tumor – even if the surgery is considered “successful” – it’s nearly impossible to ensure […]

Cancer News

Leukemia Lymphoma Treatment Research Shows Promise: New drug cocktail unlocks potential of new Leukaemia treatment

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(SOURCE: UNIVERSITY OF MANCHESTER) – A new combination of drugs, tested by University of Manchester scientists, has significantly enhanced the survival of laboratory mice with lymphoma. According to the team, the effect of Obinutuzumab – a first-line treatment for non-Hodgkin lymphoma and leukaemia – is significantly enhanced when combined with drugs that stimulate the immune system. […]

Cancer News

Cancer Treatment Research News: Bodywide immune response important for fighting cancer

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(SOURCE: STANFORD UNIVERSITY MEDICAL CENTER) – Effective anti-tumor activity requires a systemic, rather than only a local, immune response at the tumor site. A Stanford study may help clinicians pinpoint why only some cancer patients respond to immunotherapies. Fighting off cancer requires the concerted efforts of immune molecules throughout the body, rather than just in the tumor […]

Brain Cancer

Brain Cancer Research: Precision medicine advances pediatric brain tumor diagnosis and treatment

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(SOURCE: DANA-FARBER CANCER INSTITUTE) – Precision medicine — in which diagnosis and treatments are keyed to the genetic susceptibilities of individual cancers — has advanced to the point where it can now impact the care of a majority of children with brain tumors, a new study by investigators at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center suggests. […]