(SOURCE: OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER) – An international panel of experts has released updated evidence-based and expert-opinion-based recommendations for the diagnosis and treatment of acute myeloid leukemia (AML) in adults. The recommendations were issued by the European LeukemiaNet (ELN) and published in the journal Blood. The paper’s senior author was Clara D. Bloomfield, MD, Distinguished […]
(SOURCE: ST. JUDE CHILDREN’S RESEARCH HOSPITAL) – International researchers led by St. Jude Children’s Research Hospital have identified genetic alterations that can be used to guide treatment of pediatric acute megakaryoblastic leukemia, which has a dismal prognosis. Research led by St. Jude Children’s Research Hospital has identified three genetic alterations to help identify high-risk pediatric patients with […]
(SOURCE: UNIVERSITY OF MANCHESTER) – A new combination of drugs, tested by University of Manchester scientists, has significantly enhanced the survival of laboratory mice with lymphoma. According to the team, the effect of Obinutuzumab – a first-line treatment for non-Hodgkin lymphoma and leukaemia – is significantly enhanced when combined with drugs that stimulate the immune system. […]
(SOURCE: GOETHE UNIVERSITY FRANKFURT) – Because it is impossible to predict which acute myeloid leukaemia (AML) patients will benefit, all patients are routinely treated with chemotherapy although only some will respond to the treatment. Researchers from Goethe-University Frankfurt have now discovered a novel biomarker that enables the detection of therapy responders and non-responders with high accuracy. In […]
(SOURCE: NORTHWESTERN UNIVERSITY) – Scientists identify molecular therapy to prevent growth of pediatric leukemia. Northwestern Medicine scientists have discovered the genetic driver of a rare and lethal childhood leukemia and identified a targeted molecular therapy that halts the proliferation of leukemic cells. The finding also has implications for treating other types of cancer. Mixed lineage leukemia (MLL) […]
(SOURCE: CINCINNATI CHILDREN’S HOSPITAL MEDICAL CENTER) – Cincinnati Children’s researchers report in Nature Immunology a new mechanism that controls blood cell function and several possible molecular targets for treating myelodysplasia syndromes (MDS) – a group of pre-malignant disorders in which bone marrow does not produce enough healthy blood cells. MDS can lead to acute myeloid leukemia (AML), […]
(SOURCE: UNIVERSITY OF CINCINNATI ACADEMIC HEALTH CENTER) – Cancer researchers at the University of Cincinnati have found an obesity-associated protein’s role in leukemia development and drug response which could lead to more effective therapies for the illness. The study, published in the Dec. 22 online edition of Cancer Cell and led by Jianjun Chen, PhD, associate professor […]
(SOURCE: UT SOUTHWESTERN MEDICAL CENTER) – UT Southwestern Medical Center researchers have found that intermittent fasting inhibits the development and progression of the most common type of childhood leukemia. This strategy was not effective, however, in another type of blood cancer that commonly strikes adults. “This study using mouse models indicates that the effects of fasting on blood […]
(SOURCE: KU LEUVEN) – Twenty to forty percent of the patients with the type of leukaemia known as multiple myeloma have a defect in the ‘protein factory’ of the cell: the ribosome. These patients have a poorer prognosis than patients with intact ribosomes. At the same time, they respond better to a drug that already exists. These are the findings […]
(SOURCE: FRED HUTCHINSON CANCER RESEARCH CENTER) – Oncologists are beginning to leverage unique genomic characteristics of pediatric AML to improve treatment and prognosis. By Sabrina Richards / Fred Hutch News Service Acute myeloid leukemia is the deadliest leukemia among children. Only half of patients will achieve long-term remission. But scientists see change on the horizon. Taking advantage of […]
(SOURCE: OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER) – Two genetic mutations known to play a role in many solid cancers might also help explain why a subset of acute myeloid leukemia (AML) patients develop the disease, according to new research from The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. […]
(SOURCE: AMERICAN SOCIETY OF HEMATOLOGY) – An abstract presented during the 58th American Society of Hematology (ASH) Annual Meeting and Exposition in San Diego identifies inherited genetic mutations in the gene IKZF1 that confer a higher likelihood of developing pediatric acute lymphocytic leukemia (ALL). The findings are among the latest evidence to point to a strong inherited genetic basis […]
(SOURCE: UNIVERSITY OF LIVERPOOL) – Patients with a chronic type of leukaemia could safely reduce the side effects of life-long treatment by cutting their dose in half, according to the results of a University of Liverpool led study presented at an international conference in America this week. Drugs known as tyrosine kinase inhibitors (TKI) have drastically improved […]
(SOURCE: UNIVERSITY OF PENNSYLVANIA SCHOOL OF MEDICINE) Lymphoma and Multiple Lyeloma Research News – Researchers from the Perelman School of Medicine at the University of Pennsylvania and The Children’s Hospital of Philadelphia (CHOP) will present the latest advances from their studies of personalized cellular therapies for blood cancers during the 58th Annual Meeting of the American […]
(WASHINGTON UNIVERSITY SCHOOL OF MEDICINE) According to a recent press release, patients with the most lethal form of acute myeloid leukemia (AML) – based on genetic profiles of their cancers – typically survive for only four to six months after diagnosis, even with aggressive chemotherapy. But new research indicates that such patients, paradoxically, may live […]
(UNIVERSITY OF CALIFORNIA – LOS ANGELES) According to a recent press release, a synthetic version of a rare toxin produced by a sea creature appears to hold promise for treating many different types of cancer while minimizing the harmful side effects of widely used chemotherapy drugs.
(UNIVERSITY OF CHICAGO MEDICAL CENTER) According to a recent press release, after nearly two decades of unsuccessful attempts, researchers from the University of Chicago Medicine and the Cincinnati Children’s Hospital Medical Center have created the first mouse model for the most common form of infant leukemia. Their discovery, published in the Nov. 14, 2016, issue […]
(ST. JUDE CHILDREN’S RESEARCH HOSPITAL) According to a recent press release, an international research team led by St. Jude Children’s Research Hospital investigators has uncovered details of a new, high-risk subtype of acute lymphoblastic leukemia (ALL) as well as a possible targeted therapy. The findings appear today in the scientific journal Nature Communications.
(UNIVERSITY OF CALIFORNIA – SAN DIEGO) According to a press release, researchers at University of California San Diego School of Medicine and Moores Cancer Center discovered that a cell surface molecule known as CD98 promotes acute myeloid leukemia (AML). The study, published October 27 by Cancer Cell, also shows that inhibiting CD98 with the therapeutic antibody […]
(EMORY HEALTH SCIENCES / EurekAlert) According to a recent press release from Emory Health Sciences, certain DNA mutations in bone cells that support blood development can drive leukemia formation in nearby blood stem cells, researchers from Winship Cancer Institute, Emory University and Children’s Healthcare of Atlanta have found.