What is Danon Disease?
(Symptoms, Causes & Treatment)
According to the U.S. National Library of Medicine, Danon disease is a condition which is identified by weakening of the heart muscle (cardiomyopathy); weakening of the skeletal muscles (used for movement), (myopathy); and intellectual disability. Males with Danon disease usually develop the condition earlier than females and are more severely affected. Signs and symptoms begin in childhood or adolescence in most affected males and in early adulthood in most affected females. Affected males, on average, live to age 19, while affected females live to an average age of 34.
People with Danon disease can have other heart-related signs and symptoms, including a palpitations, arrhythmia, or chest pain. Many affected individuals have abnormalities of the electrical signals that control the heartbeat (conduction abnormalities). People with Danon disease are often affected by a specific conduction abnormality known as cardiac preexcitation. The type of cardiac preexcitation most often seen in people with Danon disease is called the Wolff-Parkinson-White syndrome pattern.
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