Acquired aplastic anemia is usually considered an autoimmune disease. It is a rare blood disorder which results in the failure of the bone marrow failure to produce blood cells. In people who have aplastic anemia, the body doesn’t make enough red blood cells, white blood cells, and platelets. This is because the bone marrow’s stem cells are damaged. (Aplastic anemia also is called bone marrow failure.) In acquired aplastic anemia, an almost complete absence of hematopoietic stem cells results in low levels of red and white blood cells and platelets (pancytopenia). Symptoms of aplastic anemia are those of anemia, bleeding, and infection. Although bone marrow failure can occur secondary to other disorders, most aplastic anemia is due to the immune system mistakenly targeting the bone marrow (autoimmunity). Most patients can respond to therapy that suppresses the immune system.
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