What is Sickle Cell Disease? (Definition)
Sickle cell disease (SCD) refers to a group of inherited red blood cell disorders. People with SCD have abnormal hemoglobin (a protein in red blood cells that carries oxygen throughout the body) called hemoglobin S or sickle hemoglobin, in their red blood cells.
According to the Department of Health and Human Services, people who have SCD inherit two abnormal hemoglobin genes, one from each parent. In all forms of SCD, at least one of the two abnormal genes causes a person’s body to make hemoglobin S. When a person has two hemoglobin S genes, Hemoglobin SS, the disease is called sickle cell anemia. This is the most common and often most severe kind of SCD.
Hemoglobin SC disease and hemoglobin Sβ thalassemia (thal-uh-SEE-me-uh) are two other common forms of SCD.
Some Forms of Sickle Cell Disease Include:
- Hemoglobin SS
- Hemoglobin SC
- Hemoglobin Sβ0 thalassemia
- Hemoglobin Sβ+ thalassemia
- Hemoglobin SD
- Hemoglobin SE
Sickle cell disease is a life-long illness. The severity of the disease varies widely from person to person.
See below for updated news and information regarding Sickle Cell Disease including new research, treatments and advancements.
Latest Sickle Cell Disease News
New Gene Editing Technology May Offer Future Hope for Blood Disorders Like Beta Thalassemia and Sickle Cell